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01.11.2010
Holý Antonín
Prof. RNDr., DrSc.
Born September 1, 1936
- Organic chemistry
- Member of Learned Society since 1999
Employment and academic positions:
- 1963-present, Institute of Organic Chemistry and Biochemistry AS CR (IOCB);
- 1967, senior scientist;
- 1983, Head, nucleic acid chemistry group;
- 1986, DrSc.;
- 1987, Head, Bioorganic Chemistry Department;
- 1994-2002, Director, IOCB
Membership and positions in international organizations and societies:
- International Union of Pure and Applied Chemistry
- International Society for Antiviral Research
- International Society of Nuclear Acids Chemistry
- American Society for Microbiology
Notable awards:
- 1998, Dr.h.c., Palacký University, Olomouc
- 1998, Hanuš Medal, Czechoslovak Chemical Society
- 1999, Descartes Prize of European Union
- 2001, Elion Award, International Society for Antiviral Research
- 2002, State Medal „For Merit“
- 2004, Honorary Medal, AS CR, “De Scientia et humanitate optime meritis“
Selected publications:
- De Clercq E., Holý A., Rosenberg I., Sakuma T., Balzarini J., Maudgal P. C.: A novel selective broad-spectrum anti-DNA virus agent. Nature 323, 464-467, 1986
- De Clercq E., Sakuma T., Baba M., Pauwels R., Balzarini J., Rosenberg I., Holý A.: Antiviral activity of phosphonylmethoxyalkyl derivatives of purine and pyrimidines. Antiviral Res. 8, 261-272, 1987
- Snoeck R., Sakuma T., De Clercq E., Rosenberg I., Holý A.: (S)-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine, a potent and selective inhibitor of human cytomegalovirus replication. Antimicrob. Agents Chemother. 32, 1839-1844, 1988
- Balzarini J., Naesens L., Herdewijn P., Rosenberg I., Holý A., Pauwels R., Baba M., Johns D. G., De Clercq E.: Marked in vivo antiretrovirus activity of 9-(2-phosphonylmethoxyethyl)adenine, a selective anti-human immunodeficiency virus agent. Proc. Natl. Acad. Sci. U. S. A. 86, 332-336, 1989
- Balzarini J., Holý A., Jindrich J., Naesens L., Snoeck R., Schols D., De Clercq E.: Differential antiherpesvirus and antiretrovirus effects of the (S) and (R) enantiomers of acyclic nucleoside phosphonates: potent and selective in vitro and in vivo antiretrovirus activities of (R)-9-(2-phospho-nomethoxypropyl)-2,6-diaminopurine. Antimicrob. Agents Chemother. 37, 332-338, 1993
- Holý A., Gunter J., Dvořáková H., Masojídková M., Andrei G., Snoeck R., Balzarini J., De Clercq E.: Structure-antiviral activity relationship in the series of pyrimidine and purine N-[2-(2-phospho-nomethoxy)ethyl] nucleotide analogues. 1. Derivatives substituted at the carbon atoms of the base. J. Med. Chem. 42, 2064-2086, 1999
- Holý A., Votruba I., Tloušťová E., Masojídková M.: Synthesis and cytostatic activity of N-[2-(phosphonomethoxy)alkyl] derivatives of N6-sub-stituted adenines, 2,6-diaminopurines and related compounds. Collect. Czech. Chem. Commun. 66, 1545-1592, 2001
- Balzarini J., Pannecouque C., De Clercq E., Aquaro S., Perno C. F., Egberink H., Holý A.: Antiretrovirus activity of a novel class of acyclic pyrimidine nucleoside phosphonates. Antimicrob. Agents Chemother 46, 2185-2193, 2002
- Holý A., Votruba I., Masojidková M., Andrei G., Snoeck R., Naesens L., De Clercq E., Balzarini J.: 6-[2-(Phosphonomethoxy)alkoxy]pyrimidines with antiviral activity. J. Med. Chem. 45, 1918-1929, 2002
- Keith K. A., Hitchcock M. J. M., Lee W. A., Holý A., Kern E. R.: Evaluation of Phosphonate Nucleotides, Their Analogs and Prodrugs for Inhibition of Orthopoxvirus Replication. Antimicrob. Agents Chemother. 47, 2193-2198, 2003
Připomeňte si diskuse Učené společnosti o open access, o predátorských vydavatelstvích a o dalších aspektech vědeckého publikování:
11.ledna 2023, moderoval Jan Trlifaj:
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- prof. Michal Hocek (Učená společnost ČR a ÚOCHB AV ČR)
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- doc. Daniel Münich (CERGE-EI)
- doc. David Kosař (Právnická fakulta Masarykovy univerzity)
- Ing. Martin Svoboda (NTK a CzechELib)
- dr. Václav Štětka (Loughborough University, UK)
- prof. Jan Trka (2. LF Univerzity Karlovy)
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