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Pačes Václav

Prof., RNDr., DrSc., dr.h.c.
Born February 2, 1942

  • Genomics and bioinformatics
  • Member of the Learned Society since 1994 (Founding member)
  • 2010-2012 LS Chairman
  • 1998-2002, member of the LS Council     

Educational and professional preparation:

  • 1959, IV. Qualification class: press operator, welder, ČKD Vagónka Tatra Smíchov, Praha;
  • 1965, graduate, biochemistry, Faculty of Natural Sciences, Charles University, Prague;
  • 1970, RNDr.; 1968, CSc.(PhD), Institute of Organic Chemistry and Biochemistry, CSAS (IOCB), Prague;
  • 1988, DrSc., Institute of Molecular Genetics, CSAS;
  • 1990, Associate Professor of biochemistry, Institute of Chemical Technology (ICT), Prague;
  • 1994, Full Professor of biochemistry, ICT

Employment and academic positions:

  • 1965-1968, PhD student, IOCB, CSAS;
  • 1968-1969, Research associate, Department of Biophysics and Theoretical Biology, University of Chicago, USA;
  • 1969-1970, Post-doctoral student, Department of Biochemistry, McMaster University, Hamilton, Ontario, Canada;
  • 1970-1977, scientist and later senior scientist, IOCB, CSAS;
  • 1977-2005, Head, Department of Genomics and Bioinformatics, Institute of Molecular Genetics, CSAS and AS CR;
  • 1990-1991, Visiting scientist, Human Genetics Department, Yale University, New Haven, USA.
  • Shorter stays by invitation: 1980, Department of Biochemistry, University of Bristol, England; 1986, Institute of Molecular Biology, Consejo Superior de Investigaciones Científicas (CSIC), Madrid, Spain; 1988, Department of Genetics, University of Seville, Spain, (organized course on DNA sequencing); 1989, Institute of Applied Biochemistry, Mitake, Japan; invited lecture at the FEBS Congress, Rome 1989;
  • 1999-2005, Director, Institute of Molecular Genetics, AS CR;
  • 2005-2009, president, AS CR

Membership in selected domestic scientific bodies:

  • Czech Society for Biochemistry and Molecular Biology (Chairman 1990-2018)

Membership and positions in international organizations and societies:

  • 1997, elected member, European Molecular Biology Organisation (EMBO)
  • 2000, Vice-Chairman, European Molecular Biology Conference (EMBC)
  • 1997, elected member, European Academy of Sciences and Arts
  • 2002, elected member, European Academy of Sciences
  • 2002, Federation of European Biochemical Societies (FEBS), elected: Publications Committee member, Secretary General 2014-2022
  • 2002, member, editorial board, European Journal of Biochemistry
  • 2003, editor, Research in Microbiology

Notable awards:

  • 1980, Prize, Czech Literary Fund (for the best publication)
  • 1987, Academy Award
  • 1989, State award (for science)
  • 1992, CSAS award (for promotion of science)
  • 1988, Annual lecture in honour of J. L. Fischer, Palacký University
  • 2008, Balling Medal (ICT)
  • 2008, De Scientia Humanitate Optime Meritis (Academy)
  • 2009, Medal of the Slovak Academy of Sciences
  • 2010, Votoček Medal (ICT)
  • 2012, Gregor Mendel Medal (Academy)

Selected publications:

  • Pačes V., Doskočil J., Šorm F.: Incorporation of 5-azacytidine into nucleic acids of Escherichia coli. Biochim. Biophys. Acta 161, 352-360 (1968)
  • Pačes V., Doskočil J., Šorm F.: The effect of 5-azacytidine on the synthesis of ribosomes in Escherichia coli. FEBS Letters 1, 55-58 (1968)
  • Pačes V., Werstiuk E., Hall R. H.: Conversion of N6(isopentenyl)ade-nosine to adenosine by enzyme activity in tobacco tissue. Plant Physiol. 48, 775-778 (1971)
  • Pačes V., Vlček C., Urbánek P.: Nucleotide sequence of the late region of Bacillus subtilis phage PZA, a close relative of j29. Gene 44, 107-114 (1986)
  • Hostomský Z., Smrt J., Arnold L., Točík Z., Pačes V.: Solid-phase assembly of cow colostrum trypsin inhibitor gene. Nucleic Acids Res. 15, 4849-4856 (1987)
  • Kozmík Z., Arnold L., Pačes V.: Multiple sets of adjacent mE1 and oct-1 binding sites upstream of the pseudorabies virus immediate-early gene promoter. Virology 182, 239-249 (1991)
  • Pačes V., Rosenberg L.E., Fenton V., Kalousek F.: The b-subunit of the mitochondrial processing peptidase from rat liver: gene cloning and sequencing and comparison to a new family of metallopeptidases. Proc. Natl. Acad. Sci. USA 90 (1993) 5355-5358
  • Dujon B. et al. (98 authors, Beneš V., Pačes V., Vlček Č. included): The complete nucleotide sequence of yeast chromosome XV. Nature 387, 98-102 (l997)
  • Pačes V., Pivec L., Teich A. (Eds.): Science Evaluation and Its Management. IOS Press, Amsterdam 1999
  • Pečenková T., Pačes V.: Molecular phylogeny of j29-like phages and their relatedness to other protein-primed replicating phages and other phages hosted by gram-positive bacteria. J. Mol. Evol. 48, 197-208 (1999)
  • Pačes J., Pavlíček A., Pačes V.: HERVd: database of human endogenous retroviruses, Nucleic Acids Res. 30, 205-206 (2002)
  • Ruivenkamp A.L., ….Vlček Č….Pačes V….Démant P. (20 authors in total): Ptprj is a candidate for the mouse colon-cancer susceptibility locus Scc1 and is frequently deleted in human cancers. Nature Genetics 31, 295-300 (2002)
  • Pačes J., Pavlíček A., Zika R., Kapitonov V.V., Jurka J., Pačes V.: HERVd: the Human Endogenous Retroviruses Database. Update Nucleic Acids Res. 32, 50 (2004)