Calendar

20. – 21.05.2019

XXV AGM

20. 5 Karolinum – all day, evening: Vila Lanna21. 5. CAS building, all day

Lukáš Jiří

Born 31. October, 1961

  • Cell & cancer biology
  • Honorary member of the Learned Society since 2005

Educational and professional preparation:

  • (1981-86) Veterinary University, Brno, Czech Republic
  • (1987-90) Institute of Systematic and Ecological Biology, Czech Academy of Sciences, Brno, Czech Republic
  • (1990 & 1991) Department of Biochemistry (Paul Nurse), Oxford, UK
  • (1992-93) Cell Cycle Group (Giulio Draetta), EMBL, Heidelberg, Germany
  • Since 2005: Director, Centre for Genotoxic Stress Research
  • Institute of Cancer Biology, Danish Cancer Society

Research interests:

  • Regulation of the mammalian cell division cycle and its response to genotoxic stress
  • Non-invasive imaging of molecular events in living mammalian cells

Notable awards:

  • Fellowships: EMBO, UICC, ICRF
  • Grants: Human Frontier Scientific Programme; European Union (FP6), European Science Foundation, Danish Cancer Society; Danish National Research Foundation.
  • Young Danish Cancer Researcher Prize (1995)
  • Elected EMBO Member (2002)
  • Alfred Benzons Foundation Prize (2002)
  • Novo Nordisk Foundation Prize (2003)
  • G. J. Mendel Honorary Medal (2003)
  • Associated professor, Aarhus University (2005)
  • Honorary member of the Learned Society of the Czech Republic (2005)
  • Senior Researcher Prize, Danish Cancer Society (2006)

Patents:

  • International patent on the Cdc25A DNA damage checkpoint pathway as a target for cancer therapeutics.

Selected publications:

97 research papers in peer reviewed journals; 25 review articles; 4 book chapters.
The references of 10 key papers are provided below:

  • Lukas, J., Parry, D., Aagaard, L., Mann, D.J., Bartkova, J., Strauss, M., Peters, G., and Bartek, J. Retinoblastoma-protein-dependent cell-cycle inhibition by the tumour suppressor p16. Nature 375, 503-506 (1995).
  • Lukas, C., Sørensen, C.S., Kramer, E., Santoni-Rugiu, E., Lindeneg, C., Peters, J. M., Bartek, J., and Lukas, J. Accumulation of cyclin B1 requires E2F and cyclin-A-dependent rearrangement of the anaphase-promoting complex. Nature 401, 815-818 (1999).
  • Mailand, N., Falck, J., Lukas, C., Syljuåsen R., Welcker, M., Bartek, J., and Lukas, J. Rapid destruction of human Cdc25A in response to DNA damage. Science 288, 1425-1429 (2000).
  • Falck, J., Mailand, N., Syljuasen, R. G., Bartek, J. & Lukas, J. The ATM-Chk2-Cdc25A checkpoint pathway guards against radioresistant DNA synthesis. Nature 410, 842-847 (2001).
  • Sørensen, C. S., Syljuåsen, R. G., Falck, J., Schroeder, T., Rönnstrand, L., Zhou, B. B., Bartek, J., and Lukas, J. Chk1 regulates the S-phase checkpoint by coupling the physiological turnover and ionizing radiation-induced accelerated proteolysis of Cdc25A. Cancer Cell 3, 247-258 (2003).
  • Lukas, C., Falck, J., Bartkova, J., Bartek, J., and Lukas, J. Distinct spatio-temporal dynamics of mammalian checkpoint regulators induced by DNA damage. Nature Cell Biology 5, 255-260 (2003).
  • Lukas, J., and Bartek, J. The heart of the cycle. Nature, 432, 564-567 (2004).
  • Bartkova, J., Horejsi, Z., Koed, K., Guldberg, P., Krämer, A., Sehested, M., Nesland, J., Lukas, C., Ørntoft, T., Lukas, J., and Bartek. J. DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis. Nature, 434, 864-870 (2005).
  • Bartek, J., and Lukas, J. Balancing life-or-death decisions. Science, 314, 261-262 (2006).
  • Mailand, N., Bekker-Jensen, S., Bartek, J., and Lukas, J. Destruction of Claspin by SCF TrCP restrains Chk1 activation and facilitates recovery from genotoxic stress. Molecular Cell, 23, 307-318 (2006).

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News

07.05.19

XXV. General Assembly

The Czech Learned Society is holding its XXV. General Assembly on 20 and 21 May 2019. The Learned Society’s awards in the “Young Scientist” and “Grammar School Student” categories, Teaching Awards for pedagogic workers who promote interest in science and research at grammar schools and the Learned Society’s medals for meritorious contributions to the advance of science will be presented during a ceremony on 20 May at the Karolinum. Lectures by renowned scientists will also be presented. The second day will be reserved for the working part of the meeting, in the building of the Academy of Sciences of the Czech Republic.

06.05.19

Document on issues concerning the concept of European historiography and the present-day EU

Learned Society Fellow prof. Jiří Pešek signed a Document on issues concerning the concept of European historiography and the present-day EU.

05.05.19

Invitation to the Bolzano Lecture

Invitation to the Bolzano Lecture by prof. Kip S. Thorne on May 15, 2019 and other lectures on May 16 and May 17, 2019

Invitation (PDF, 707 kB)