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Kopeček Jindřich

Distinguished Professor, D.Sc.
Born January 27, 1940 in Strakonice

  • Chemist
  • Member of Learned Society since 1998
Institution:
  • Department of Pharmaceutics and Pharmaceutical Chemistry, Department of Bioengineering, University of Utah, Salt Lake City, Utah 84112, USA

Educational and professional preparation:

  • 1990, D.Sc., chemistry, Czechoslovak Academy of Sciences (CSAS);
  • 1967-1968, Post-doctoral Fellow, National Research Council of Canada, Ottawa;
  • 1965, Ph.D., macromolecular chemistry, Institute of Macromolecular Chemistry (IMC) CSAS;
  • 1961, M.S., macromolecular chemistry, Institute of Chemical Technology, Prague

Employment and academic positions:

  • 2002-present, Distinguished Professor of Pharmaceutics and Pharmaceutical Chemistry, Distinguished Professor of Bioengineering, University of Utah;
  • 1999-2004, Chairman, Department of Pharmaceutics and Pharmaceutical Chemistry, University of Utah;
  • 1989-2002, Professor of Pharmaceutics and Pharmaceutical Chemistry, Professor of Bioengineering, University of Utah;
  • 1986-present, Co-Director, Center for Controlled Chemical Delivery, University of Utah;
  • 1983-2000, Visiting Professor, Université Paris-Nord;
  • 1986-1988, University of Utah; 1999, Tokyo Women’s Medical University;
  • 1972-1988, Head, Laboratory, Institute of Macromolecular Chemistry, CSAS;
  • 1965-1972, Scientific Officer, Institute of Macromolecular Chemistry, CSAS

Membership and positions in international organizations and societies:

  • Controlled Release Society: President 1995-1996; Vice-President 1993-1994; member, Board of Governors 1988-1991; Chairman, Nagai Award Committee, 2002-present.
  • Member, Biomaterials Society
  • Member, American Association for the Advancement of Science
  • Member, American Association for Cancer Research
  • Member, American Association of Pharmaceutical Scientists
  • Member, Society for Molecular Recognition
  • Member, American Society for Photobiology

Notable awards:

  • 2004, Chair, Gordon Research Conference on Drug Carriers in Medicine and Biology
  • 2003-present,, Chair, National Institutes of Health, Biomaterials and Biointerfaces Study Section
  • 2003, Heyrovský Medal for merit in the chemical sciences, Academy of Sciences of the Czech Republic
  • 2003, AAPS PharmSci and AAPS PharmSciTech Outstanding Use of Technology, Award for best publication in AAPS PharmSci, American Association of Pharmaceutical Scientists
  • 2001, Paul Dawson Biotechnology Award, American Association of Colleges of Pharmacy
  • 2000, Millennial Pharmaceutical Scientist, Millennial World Congress of Pharmaceutical Sciences
  • 1999, Fellow of Biomaterials Science and Engineering, International Union of Societies of Biomaterials Science and Engineering
  • 1999, J. Heller Award for best publication in Journal of Controlled Release
  • 1999, Founders Award, Controlled Release Society
  • 1995, Clemson Award (for Basic Research, Society for Biomaterials)
  • 1995, Fellow, American Institute for Medical and Biological Engineering
  • 1994, Fellow, American Association of Pharmaceutical Scientists
  • 1993, Distinguished Research Award, University of Utah
  • 1992, Program Chairman, 19th International Symposium on Controlled Release of Bioactive Materials, Orlando, Florida
  • 1990, Barre’s Lecture, Université de Montreal

Member, Editorial Boards:

  • 1973-1996, Polymers in Medicine (Wroclaw)
  • 1986-1998, New Polymeric Materials
  • 1992-1998, Polymer Gels and Networks
  • 1980-present, Biomaterials
  • 1981-present, Critical Reviews in Therapeutic Drug Carrier Systems
  • 1984-present, Journal of Controlled Release
  • 1986-present, Journal of Bioactive and Compatible Polymers
  • 1987-present, Journal of Biomaterials Science
  • 1991-present, Drug Delivery
  • 1992-present, European Journal of Pharmaceutics and Biopharmaceutics
  • 1993-present, Bioconjugate Chemistry
  • 1995-present, Pharmaceutical Research
  • 1999-present, The AAPS Journal (formerly AAPS PharmSci)
  • 2001-present, Advanced Drug Delivery Reviews
  • 2002-present, Journal of Drug Delivery Science and Technology (formerly STP Pharma Sciences)
  • 2002-present, European Journal of Pharmaceutical Sciences

Research interests:

  • Biorecognition of Macromolecules
  • Bioconjugate Chemistry
  • Drug Delivery Systems
  • Genetically Engineered Materials
  • Self-Assembly of Macromolecules

Notable publications:

  • N. Nishiyama, A. Nori, A. Malugin, Y. Kasuya, P. Kopeckova, J. Kopecek: Free and N-(2-Hydroxypropyl)methacrylamide (HPMA) Copolymer-bound Geldanamycin Derivative Induce Different Stress Responses in A2780 Human Ovarian Carcinoma Cells. Cancer Res. 63, 7876-7882 (2003)
  • A. Nori, K.D. Jensen, M. Tijerina, P. Kopeckova, J. Kopecek, Tat Conjugated Synthetic Macromolecules Facilitate Cytoplasmic Drug Delivery to Human Ovarian Carcinoma Cells. Bioconjugate Chem. 14, 44-50 (2003)
  • J. Kopecek, Smart and Genetically Engineered Biomaterials and Drug Delivery Systems, Eur. J. Pharm. Sci. 20, 1-16 (2003)
  • D. Wang, M. Pechar, W. Li, P. Kopeckova, D. Brömme, J. Kopecek: Inhibition of Cathepsin K with Lysosomotropic Macromolecular Inhibitors, Biochemistry 41, 8849-8859 (2002)
  • A. Tang, J. Kopecek, Presentations of Epitopes on Peptide Scaffolds and Selection of Lymphoma-Targeting Moieties Based on Epitope Recognition. Biomacromolecules 3, 421-431 (2002)
  • J.-G. Shiah, M. Dvorak, P. Kopeckova, Y. Sun, C. M. Peterson, J. Kopecek: Biodistribution and Antitumor Efficacy of Long-Circulating N-(2-Hyd-roxy-propyl)methacrylamide Copolymer-Doxorubicin Conjugates in Nude Mice,
    Eur. J. Cancer
    37, 131-139 (2001)
  • T. Minko, P. Kopeckova, J. Kopecek: Efficacy of Chemotherapeutic Action of HPMA Copolymer-Bound Doxorubicin in a Solid Tumor Model of Ovarian Carcinoma.
    Int. J. Cancer, 86, 108-117 (2000)
  • J.-G. Shiah, Y. Sun, C. M. Peterson, R. C. Straight, J. Kopecek: Antitumor Activity of HPMA Copolymer-Meso Chlorin e6 and Adriamycin Conjugates in Combination Treatments. Clin. Cancer Res. 6, 1008-1015 (2000)
  • Z.-R. Lu, P. Kopeckova, J. Kopecek: Polymerizable Fab’ Antibody Fragments for Targeting of Anticancer Drugs. Nature Biotechnology 17, 1101-1104 (1999)
  • C. Wang, R. J. Stewart, J. Kopecek: Hybrid Hydrogels Assembled from Synthetic Polymers and Coiled-Coil Protein Domains. Nature 397, 417-420 (1999)

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News

20.05.19

XXV. General Assembly of the Learned Society of the Czech Republic

The ceremonial part of the XXV. General Assembly of the Learned Society, at which the Medals of the Learned Society of the Czech Republic Societas Scientarium Bohemica Ad Laudem et Honorem and the awards of the Learned Society of the Czech Republic in the “Young Scientist” and “Grammar School Student” categories were presented, took place on Monday 20 May 2019 in the Great Hall of the Carolinum.

19.05.19

Bolzano lecture by prof. Kip S. Thorne

American physicist Kip S. Thorne, recipient of the Nobel Prize for 2017 for detection of gravitational waves, visited Prague at the invitation of he Learned Society. He held a series of “Bolzano lectures” and a lecture titled “Creating Gravitational-Wave Astronomy” for the Learned Society on 15 May 2019 in the Blue Auditorium of the Carolinum. The lecture was held with the support of the Karel Janeček Foundation and was received very enthusiastically.

07.05.19

XXV. General Assembly

The Czech Learned Society is holding its XXV. General Assembly on 20 and 21 May 2019. The Learned Society’s awards in the “Young Scientist” and “Grammar School Student” categories, Teaching Awards for pedagogic workers who promote interest in science and research at grammar schools and the Learned Society’s medals for meritorious contributions to the advance of science will be presented during a ceremony on 20 May at the Karolinum. Lectures by renowned scientists will also be presented. The second day will be reserved for the working part of the meeting, in the building of the Academy of Sciences of the Czech Republic.