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Závada Jan

RNDr., DrSc.
Born December 10, 1933 in Prague

  • Genetics of viruses, molecular oncology
  • Member of Learned Society since 1994 (Founding member)

Educational and professional preparation:

  • 1952-1956, Faculty of Natural Science, Charles University, Prague;
  • 1958-1962, post-graduate student, Institute of Virology, Slovak Academy of Sciences (SAS), Bratislava


  • 1956-1992 Institute of Virology, SAS;
  • 1993-present, Institute of Molecular Genetics, Academy of Sciences of Czech Republic (AS CR);
  • 1965-1966, Institute of Virology, Glasgow (Scotland) (12 months),
  • 1969-1975, Imperial Cancer Research Fund Laboratories, London (9 plus 6 months);
  • 1982-1983, Harvard Medical School, Boston (Mass.) (12 months).

Membership and positions in international organizations and societies:

  • Member, European Molecular Biology Organization
  • Member, European Association for Cancer Research
  • Member, European Tumour Virus Group

Notable awards:

  • 1981, National prize (for the construction of viral pseudotypes and their use in diagnostics)
  • 1984, Award, SAS, and Award, Czechoslovak Writers’ Federation (for the popular-scientific book The Mystery of Cancer by J. Závada and V. Vonka

Selected publications:

  • J. Závada, Z. Závadová, M. Zaťovičová, L. Hyršl, I. Kawaciuk: Soluble form of carbonic anhydrase IX (CA IX) in the serum and urine of renal carcinoma patients.
    Brit. J. Cancer
    89, 1067–1071 (2003)
  • M. Ortová-Gut, S. Parkkila, Z. Vernerová, E. Rohde, J. Závada, M. Hocker, J. Pastorek, T. Karttunen, A. Gibadulinová, Z. Závadová, K-P. Knobeloch, B. Wiedermann, J. Svoboda, I. Horak, S. Pastoreková: Gastric hyperplasia in mice with targeted disruption of the carbonic anhydrase gene Car9. Gastroenterology 123, 1889–1903 (2002)
  • J. Závada, Z. Závadová, J. Pastorek, Z. Biesová, J. Ježek, J. Velek: Human tumor-associated cell adhesion protein MN/CA IX: Identification of M75 epitope and of the region mediating cell adhesion. Brit. J. Cancer 82, 1808–1813 (2000)
  • R. Opavský, S. Pastoreková, V. Zelník, A. Gibadulinová, E. J. Stanbridge, J. Závada, R. Kettmann, J. Pastorek: Human MN/Ca9 gene, a novel member of the carbonic anhydrase family: Structure and exon to protein domain relationships. Genomics 33, 480–487 (1996)
  • J. Závada, Z. Závadová, S. Pastoreková, F. Čiampor, J. Pastorek, V. Zelník: Expression of MaTu-MN protein in human tumor cultures and in clinical specimens. Int. J. Cancer 54, 268-274 (1993)
  • J. Závada: The pseudotypic paradox. (Review article). J. Gen. Virol. 63, 15-24, (1982)
  • J. Závada, L. Černý, Z. Závadová, J. Božoňová, A.D. Altstein: A rapid neutralization test for antibodies to bovine leukemia virus, with the use of rhabdovirus pseudotypes. J. Natl. Cancer Inst. 62, 95-101 (1979)
  • J. Závada: Assay methods for viral pseudotypes. In Methods in Virology 6, New York, San Francisco, London, Academic Press 1977, pp. 109-142
  • J. Závada: Pseudotypes of vesicular stomatitis virus with the coat of murine leukemia and of avian myeloblastosis viruses. J. Gen. Virol. 15, 183-191 (1972)


  • J. Závada, S. Pastoreková, J. Pastorek: MN Gene and Protein. US patent No. 5 387 676 (1995); other patents related to MN/CA IX: 5 955 075, 5 972 353, 5 981 711 (1999), 6 069 242, 6 093 548 (2000), 6 204 370 B1, 6 297 051 B1 (2001)
  • Some of the patents have a world-wide extension of validity, all are exclusively licensed to the Bayer Corp., USA

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XXV. General Assembly of the Learned Society of the Czech Republic

The ceremonial part of the XXV. General Assembly of the Learned Society, at which the Medals of the Learned Society of the Czech Republic Societas Scientarium Bohemica Ad Laudem et Honorem and the awards of the Learned Society of the Czech Republic in the “Young Scientist” and “Grammar School Student” categories were presented, took place on Monday 20 May 2019 in the Great Hall of the Carolinum.


Bolzano lecture by prof. Kip S. Thorne

American physicist Kip S. Thorne, recipient of the Nobel Prize for 2017 for detection of gravitational waves, visited Prague at the invitation of he Learned Society. He held a series of “Bolzano lectures” and a lecture titled “Creating Gravitational-Wave Astronomy” for the Learned Society on 15 May 2019 in the Blue Auditorium of the Carolinum. The lecture was held with the support of the Karel Janeček Foundation and was received very enthusiastically.


XXV. General Assembly

The Czech Learned Society is holding its XXV. General Assembly on 20 and 21 May 2019. The Learned Society’s awards in the “Young Scientist” and “Grammar School Student” categories, Teaching Awards for pedagogic workers who promote interest in science and research at grammar schools and the Learned Society’s medals for meritorious contributions to the advance of science will be presented during a ceremony on 20 May at the Karolinum. Lectures by renowned scientists will also be presented. The second day will be reserved for the working part of the meeting, in the building of the Academy of Sciences of the Czech Republic.