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Závada Jan

RNDr., DrSc.
Born December 10, 1933 in Prague

  • Genetics of viruses, molecular oncology
  • Member of Learned Society since 1994 (Founding member)

Educational and professional preparation:

  • 1952-1956, Faculty of Natural Science, Charles University, Prague;
  • 1958-1962, post-graduate student, Institute of Virology, Slovak Academy of Sciences (SAS), Bratislava


  • 1956-1992 Institute of Virology, SAS;
  • 1993-present, Institute of Molecular Genetics, Academy of Sciences of Czech Republic (AS CR);
  • 1965-1966, Institute of Virology, Glasgow (Scotland) (12 months),
  • 1969-1975, Imperial Cancer Research Fund Laboratories, London (9 plus 6 months);
  • 1982-1983, Harvard Medical School, Boston (Mass.) (12 months).

Membership and positions in international organizations and societies:

  • Member, European Molecular Biology Organization
  • Member, European Association for Cancer Research
  • Member, European Tumour Virus Group

Notable awards:

  • 1981, National prize (for the construction of viral pseudotypes and their use in diagnostics)
  • 1984, Award, SAS, and Award, Czechoslovak Writers’ Federation (for the popular-scientific book The Mystery of Cancer by J. Závada and V. Vonka

Selected publications:

  • J. Závada, Z. Závadová, M. Zaťovičová, L. Hyršl, I. Kawaciuk: Soluble form of carbonic anhydrase IX (CA IX) in the serum and urine of renal carcinoma patients.
    Brit. J. Cancer
    89, 1067–1071 (2003)
  • M. Ortová-Gut, S. Parkkila, Z. Vernerová, E. Rohde, J. Závada, M. Hocker, J. Pastorek, T. Karttunen, A. Gibadulinová, Z. Závadová, K-P. Knobeloch, B. Wiedermann, J. Svoboda, I. Horak, S. Pastoreková: Gastric hyperplasia in mice with targeted disruption of the carbonic anhydrase gene Car9. Gastroenterology 123, 1889–1903 (2002)
  • J. Závada, Z. Závadová, J. Pastorek, Z. Biesová, J. Ježek, J. Velek: Human tumor-associated cell adhesion protein MN/CA IX: Identification of M75 epitope and of the region mediating cell adhesion. Brit. J. Cancer 82, 1808–1813 (2000)
  • R. Opavský, S. Pastoreková, V. Zelník, A. Gibadulinová, E. J. Stanbridge, J. Závada, R. Kettmann, J. Pastorek: Human MN/Ca9 gene, a novel member of the carbonic anhydrase family: Structure and exon to protein domain relationships. Genomics 33, 480–487 (1996)
  • J. Závada, Z. Závadová, S. Pastoreková, F. Čiampor, J. Pastorek, V. Zelník: Expression of MaTu-MN protein in human tumor cultures and in clinical specimens. Int. J. Cancer 54, 268-274 (1993)
  • J. Závada: The pseudotypic paradox. (Review article). J. Gen. Virol. 63, 15-24, (1982)
  • J. Závada, L. Černý, Z. Závadová, J. Božoňová, A.D. Altstein: A rapid neutralization test for antibodies to bovine leukemia virus, with the use of rhabdovirus pseudotypes. J. Natl. Cancer Inst. 62, 95-101 (1979)
  • J. Závada: Assay methods for viral pseudotypes. In Methods in Virology 6, New York, San Francisco, London, Academic Press 1977, pp. 109-142
  • J. Závada: Pseudotypes of vesicular stomatitis virus with the coat of murine leukemia and of avian myeloblastosis viruses. J. Gen. Virol. 15, 183-191 (1972)


  • J. Závada, S. Pastoreková, J. Pastorek: MN Gene and Protein. US patent No. 5 387 676 (1995); other patents related to MN/CA IX: 5 955 075, 5 972 353, 5 981 711 (1999), 6 069 242, 6 093 548 (2000), 6 204 370 B1, 6 297 051 B1 (2001)
  • Some of the patents have a world-wide extension of validity, all are exclusively licensed to the Bayer Corp., USA

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Reaction to the case of Tomáš Hudlický: Members of the Learned Society of the Czech Republic support the freedom of expression

„We believe that free exchange of ideas is a key condition for the pursuit of truth and that the honest opinions should be scrutinized, challenged or rebutted but not censored or suppressed,“ say 45 members of the Learned Society in a statement regarding the retracted opinion paper by Prof. Tomáš Hudlický.


The letter by Jan Konvalinka to the President and Vice-Chancellor of the Brock University regarding the retracted article of Prof. Tomáš Hudlický

Opinions could and should be challenged, questioned or refuted but never silenced. In order to be able to think, we have to have the right to inquire, question and even offend or be mistaken,” writes Assoc. Prof. Jan Konvalinka, a biochemist at the IOCB Prague and the Vice-Rector of the Charles University, to Gervan Fearon.


Prof Miroslav Bárta receives the Česká hlava National Government Award

Learned Society member, Prof. Mgr. Miroslav Bárta, Dr. (Charles University Faculty of Arts) received the Česká hlava (Czech Head) National Government Award on 25 November 2019. A renowned Czech Egyptologist and archaeologist, Professor Bárta researches the history of ancient civilisations, the human relationship to the natural environment, and also for many years the evolution of complex societies. He leads the Czech Institute of Egyptology for archaeological and environmental research in Egypt and Sudan. His principal research interest is the period of the pyramid builders of the Old Kingdom.