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Závada Jan

RNDr., DrSc.
Born December 10, 1933 in Prague

  • Genetics of viruses, molecular oncology
  • Member of Learned Society since 1994 (Founding member)

Educational and professional preparation:

  • 1952-1956, Faculty of Natural Science, Charles University, Prague;
  • 1958-1962, post-graduate student, Institute of Virology, Slovak Academy of Sciences (SAS), Bratislava

Employment:

  • 1956-1992 Institute of Virology, SAS;
  • 1993-present, Institute of Molecular Genetics, Academy of Sciences of Czech Republic (AS CR);
  • 1965-1966, Institute of Virology, Glasgow (Scotland) (12 months),
  • 1969-1975, Imperial Cancer Research Fund Laboratories, London (9 plus 6 months);
  • 1982-1983, Harvard Medical School, Boston (Mass.) (12 months).

Membership and positions in international organizations and societies:

  • Member, European Molecular Biology Organization
  • Member, European Association for Cancer Research
  • Member, European Tumour Virus Group

Notable awards:

  • 1981, National prize (for the construction of viral pseudotypes and their use in diagnostics)
  • 1984, Award, SAS, and Award, Czechoslovak Writers’ Federation (for the popular-scientific book The Mystery of Cancer by J. Závada and V. Vonka

Selected publications:

  • J. Závada, Z. Závadová, M. Zaťovičová, L. Hyršl, I. Kawaciuk: Soluble form of carbonic anhydrase IX (CA IX) in the serum and urine of renal carcinoma patients.
    Brit. J. Cancer
    89, 1067–1071 (2003)
  • M. Ortová-Gut, S. Parkkila, Z. Vernerová, E. Rohde, J. Závada, M. Hocker, J. Pastorek, T. Karttunen, A. Gibadulinová, Z. Závadová, K-P. Knobeloch, B. Wiedermann, J. Svoboda, I. Horak, S. Pastoreková: Gastric hyperplasia in mice with targeted disruption of the carbonic anhydrase gene Car9. Gastroenterology 123, 1889–1903 (2002)
  • J. Závada, Z. Závadová, J. Pastorek, Z. Biesová, J. Ježek, J. Velek: Human tumor-associated cell adhesion protein MN/CA IX: Identification of M75 epitope and of the region mediating cell adhesion. Brit. J. Cancer 82, 1808–1813 (2000)
  • R. Opavský, S. Pastoreková, V. Zelník, A. Gibadulinová, E. J. Stanbridge, J. Závada, R. Kettmann, J. Pastorek: Human MN/Ca9 gene, a novel member of the carbonic anhydrase family: Structure and exon to protein domain relationships. Genomics 33, 480–487 (1996)
  • J. Závada, Z. Závadová, S. Pastoreková, F. Čiampor, J. Pastorek, V. Zelník: Expression of MaTu-MN protein in human tumor cultures and in clinical specimens. Int. J. Cancer 54, 268-274 (1993)
  • J. Závada: The pseudotypic paradox. (Review article). J. Gen. Virol. 63, 15-24, (1982)
  • J. Závada, L. Černý, Z. Závadová, J. Božoňová, A.D. Altstein: A rapid neutralization test for antibodies to bovine leukemia virus, with the use of rhabdovirus pseudotypes. J. Natl. Cancer Inst. 62, 95-101 (1979)
  • J. Závada: Assay methods for viral pseudotypes. In Methods in Virology 6, New York, San Francisco, London, Academic Press 1977, pp. 109-142
  • J. Závada: Pseudotypes of vesicular stomatitis virus with the coat of murine leukemia and of avian myeloblastosis viruses. J. Gen. Virol. 15, 183-191 (1972)

Patents:

  • J. Závada, S. Pastoreková, J. Pastorek: MN Gene and Protein. US patent No. 5 387 676 (1995); other patents related to MN/CA IX: 5 955 075, 5 972 353, 5 981 711 (1999), 6 069 242, 6 093 548 (2000), 6 204 370 B1, 6 297 051 B1 (2001)
  • Some of the patents have a world-wide extension of validity, all are exclusively licensed to the Bayer Corp., USA

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News

25.07.19

Luboš Perek is celebrating his 100th year

Founding fellow of the Learned Society and its doyen, astronomer doc. RNDr. Luboš Perek, DrSc, is celebrating his 100th birthday on 26 July 2019. He is an indelible part of history as the person who helped define cosmic space, he was the first to point out the issue of cosmic waste and was also a teacher to the most important Czechoslovak astronomers. Let us express our respect and admiration of the extraordinary scientific career of a person who worked tirelessly and continues to work. The Learned Society wishes Mr Perek health, optimism and joy in the oncoming years.

23.07.19

The Academy of Sciences of the Czech Republic has appealed to the Hungarian President to support academic freedom

On Friday 19 July the Academy of Sciences of the Czech Republic and the Learned Society of the Czech Republic sent a letter to Hungarian President János Ánder, in which they state their concerns regarding the situation in respect to management and funding of scientific activities in Hungary. An act, according to which not the Academy of Sciences, but a thirteen-member political committee, will decide on research, funding of scientific activities and establishment or closure of scientific workplaces, will come into force on 1 September.

07.07.19

The loss of Learned Society Fellow prof. Josef Koutecký

We regret to inform that prof. Josef Koutecký, a fellow of the Learned Society, a renowned physician and the founder of paediatric oncology in this country, passed away on 5 July 2019 at the age of 88. He founded paediatric oncology here in 1964 and a separate paediatric oncology department was then established at the Faculty Hospital in Motol, Prague in 1978.