Hocek Michal

Prof., Ing., CSc., DSc.
Born December 11, 1969 in Benešov

  • Bioorganic and medicinal chemistry
  • Member of Learned Society since 2017

Educational and professional preparation

  • 1988-1993 undergraduate study, Prague Institute of Chemical Technology, M. S. degree
  • 1993-1996 Ph.D. study, Institute of Organic Chemistry and Biochemistry (IOCB) , Academy of Sciences of the Czech Republic (supervisor Dr. A. Holý)
  • 1997 post-doctoral stay at the Department of Chemistry, Université Catholique de Louvain, Louvain-la-Neuve, Belgium (Prof. L. Ghosez)
  • 2006 DSc. degree at the Academy of Sciences of the Czech Republic
  • 2006 habilitation at the Institute of Chemical Technology Prague - Associate professor
  • 2014 named full-professor at the Charles University

Employment and academic positions

  • 1998-2002 - staff scientist at the IOCB ASCR
  • 2003 - now - Head of a Senior research group at the IOCB ASCR
  • 2011 - now - Associate and (since 2014) full-professor (part-time) at the Faculty of Science, Charles University in Prague

Membership in selected domestic scientific bodies

  • Czech Chemical Society

Membership and positions in selected international organizations and societies

  • 1998-2011 - journal Collect. Czech. Chem. Commun. - Editor-in-Chief
  • 2011-now - journal ChemBioChem - member of the Editorial Advisory Board
  • 2011-now - journal ChemPlusChem - co-chairman of the Editorial Board
  • 2013-now - F1000 faculty member for Chemical biology
  • Americal Chemical Society - member
  • International Society for Nucleosides, Nucleotides and Nucleic Acids - member

Notable awards

  • 1999 Alfred Bader Prize for excellent results of young scientist in organic and bioorganic chemistry
  • 2004 Otto Wichterle Premium for Younger Scientists
  • 2004 Prize of the Academy of Sciences for Younger Scientists
  • 2015 Praemium Academiae from the Czech Academy of Sciences

Selected publications

  • Raindlová, V.; Pohl, R.; Šanda, M.; Hocek, M. "Direct polymerase synthesis of reactive aldehyde-functionalized DNA and its conjugation and staining with hydrazines" Angew. Chem. Int. Ed. 2010, 49, 1064-1066.
  • Nauš, P.; Pohl, R.; Votruba, I.; Džubák, P.; Hajdúch, M.; Ameral, R.; Birkuš, G.; Wang, T.; Ray, A. S.; Mackman, R.; Cihlar, T.; Hocek, M. "6-(Het)aryl-7-Deazapurine Ribonucleosides as Novel Potent Cytostatic Agents" J. Med. Chem. 2010, 53, 460-470.
  • Bourderioux, A.; Nauš, P.; Perlíková, P.; Pohl, R.; Pichová, I.; Votruba, I.; Džubák, P.; Konečný, P.; Hajdúch, M.; Stray, K. M.; Wang, T.; Ray, A. S.; Feng, J. Y.; Birkus, G.; Cihlar, T.; Hocek, M. "Synthesis and significant cytostatic activity of 7-hetaryl-7-deazaadenosines" J. Med. Chem. 2011, 54, 5498-5507.
  • Kielkowski, P.; Macíčková-Cahová, H.; Pohl, R.; Hocek, M. "Transient and switchable (triethylsilyl)ethynyl protection of DNA against cleavage by restriction endonucleases" Angew. Chem. Int. Ed. 2011, 50, 8727-8730.
  • Dadová, J.; Orság, P.; Pohl, R.; Brázdová, M.; Fojta, M.; Hocek, M. "Vinylsulfonamide and acrylamide modification of DNA for cross-linking with proteins" Angew. Chem. Int. Ed. 2013, 52, 10515-10518.
  • Vaníková, Z.; Hocek, M. "Polymerase Synthesis of Photocaged DNA Resistant against Cleavage by Restriction Endonucleases" Angew. Chem. Int. Ed. 2014, 53, 6734-6737.
  • Kielkowski, P.; Fanfrlík, J.; Hocek, M. "7-Aryl-7-deazaadenine 2'-Deoxyribonucleoside Triphosphates (dNTPs): Better Substrates for DNA polymerases than dATP in Competitive Incorporations" Angew. Chem. Int. Ed. 2014, 53, 7552-7555.
  • Balintová, J.;  Špaček, J.; Pohl, R.; Brázdová, M.; Havran, L.; Fojta, M.; Hocek, M. "Azidophenyl as a click-transformable redox label of DNA suitable for electrochemical detection of DNA-protein interactions" Chem. Sci. 2015, 6, 575-587.
  • Dziuba, D.; Jurkiewicz, P.; Cebecauer, M.; Hof, M.; Hocek, M. "A Rotational Bodipy-Nucleotide: An Environment-Sensitive Fluorescence-Lifetime Probe for DNA Interactions and Applications in Live-Cell Microscopy" Angew. Chem. Int. Ed. 2016, 55, 174-178.
  • Raindlová, V.; Janoušková, M.; Slavíčková, M.; Perlíková, P.; Boháčová, S.; Milisavljevic, N.; Šanderová, H.; Benda, M.; Barvík, I.; Krasný, L.; Hocek, M. "Influence of major-groove chemical modifications of DNA on transcription by bacterial RNA polymerases" Nucleic Acids Res. 2016, 44, 3000-3012.

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