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Forejt Jiří

Prof., MUDr., DrSc., DSc. 
Born on December 28, 1944

  • Molecular genetics and genomics of laboratory mice
  • Member of Learned Society since 1999

Educational and professional preparation

  • 1962-68, MUDr. Faculty of Medicine, Charles University, Hradec Králové.
  • 1975, CSc. in genetics, Institute of Molecular Genetics, CSAS, Prague.
  • 1991, DrSc. in genetics, Charles University, Prague.
  • 2002, Associate Professor, molecular biology and genetics, Faculty of Science CU.
  • 2006, Full professor, molecular biology and genetics, Faculty of Science CU.

Employment and academic positions

  • 1968-present, Institute of Molecular Genetics of the Czech Academy of Sciences (originally Institute of Experimental Biology and Genetics, CSAS).
  • 1992-1993, 1995-1996, Visiting Professor, Department of Molecular Biology, Princeton University, Princeton, New Jersey, USA.

Membership in domestic scientific bodies

  • 2019-present, Member, International Scientific Advisory Board, Institute of Biophysics of the Czech Academy of Scienees.
  • 2003-present, Chairman, Commission for Granting Title of DSc (Research Professor) in Genetics and Genomics.
  • 2001-2005, Vice-Chairman, Council for Sciences Czech Academy of Sciences.

Membership and positions in selected international organizations and societies

  • 1984-1991, Elected member, Internat. Committee for Standardized Mouse Genetic Nomenclature.
  • 1991-present, International Mammalian Genome Society.
  • 1998-2001, Chairman, Chromosome 17 Committee.
  • 1996-2004, Howard Hughes Medical Institute–International Scholar.
  • 1999-present, European Molecular Biology Organization-Elected member.
  • 1998-2002, Slovak Commissions for Defence of Doctoral Theses - 15-02-9, 15-01-9 and 15-16-9.
  • 2003-2006, Member, EMBO YIP Selection Committee.
  • 2003-2007, Elected member, Secretariat, International Mammalian Genome Society.
  • 2006-2012, ERC Advanced Grants, member of ERC peer review panel: Genetics, Genomics, Bioinformatics and Systems Biology (LS2).
  • I2010-2011, LABEX – ANR – Member of International Jury “Laboratories of Excellence” Paris, France.
  • 2008-present, member, Scientific Advisory Board, Consortium of an Integrated Genome Research Network, Max-Planck-Institute for Molecular Genetics, Berlin
  • Member, editorial boards (in the past and present): Cytogenetics and Cell Genetics, Mouse Genome, Experimental and Clinical Immunogenetics, Roux Archives of Developmental Biology, Mammalian Genome, Folia Biologica.
    Ad hoc reviewer for: Proceedings of National Academy of Sciences USA, Genomics, Genes and Development, Genetical Research, Genome research, Genetics, J. Andrology, Gene.
  • Main organizer, international symposia: 1983, Molecular Biology of Embryonic and Teratocarcinoma Stem Cells; 1990, VIIth International Workshop of Mouse Molecular Genetics; 1996, Howard Hughes Medical Institute Conference of International Fellows- (Chairman, local organization committee), 22nd International Mouse Genome Conference, Prague, 2008.

Notable awards

  • 1984, Prize, CSAS.
  • 1999, 2009, Prize, AS CR.
  • 2004, Gregor Mendel Medal, AS CR.
  • 2007-2013, Praemium Academiae, AS CR.
  • 2009, Prize, Ministry of Education, Youth and Sports.
  • 2016, Czech Head) National Government Award (Česká hlava).
  • 2017, Silver Commemorative Medal of the Senate of the Parliament of Czech Republic.
  • 2018, The Jan Evangelista Purkyně Honorary Medals for Merit in the Biomedical Sciences of the Czech Academy of Sciences.

Selected publications

  • Mukaj A, Piálek J, Fotopulosova V, Morgan AP, Odenthal-Hesse L, Parvanov ED, Forejt J. Prdm9 Intersubspecific Interactions in Hybrid Male Sterility of House Mouse. Mol Biol Evol. 2020 Dec 16;37(12):3423-3438.
  • Wang L, Valiskova B, Forejt J. Cisplatin-induced DNA double-strand breaks promote meiotic chromosome synapsis in PRDM9-controlled mouse hybrid sterility Elife. 2018 Dec 28;7:e42511.
  •  Gregorova S, Gergelits V, Chvatalova I, Bhattacharyya T, Valiskova B,  Fotopulosova V, Jansa P, Wiatrowska D, Forejt J. Modulation of Prdm9-controlled meiotic chromosome asynapsis overrides hybrid sterility in mice. Elife. 2018 Mar 14;7:e34282.
  • Forejt J. Genetics: Asymmetric breaks in DNA cause sterility. Nature. 2016 Feb 11;530(7589):167-8.
  • Bhattacharyya T, Gregorova S, Mihola O, Anger M, Sebestova J, Denny P,  Simecek P, Forejt J. Mechanistic basis of infertility of mouse intersubspecific hybrids. Proc Natl Acad Sci U S A. 2013 Feb 5;110(6):E468-77.
  • Mihola, O., Trachtulec, Z., Vlcek, C., Schimenti, J.C., Forejt, J: A mouse speciation gene encodes a meiotic Histone H3 methyltransferase. Science 323, 373—375, 2009.
  • Gregorová, S., Divina, P., Storchova, R., Trachtulec, Z., Fotopulosova, V., Svenson, K.L., Donahue, L.R., Paigen, B., Forejt, J.: Mouse consomic strains: Exploiting genetic divergence between Mus m. musculus and Mus m. domesticus subspecies. Genome Research 18, 509-505, 2008.
  • Forejt, J.: Hybrid sterility in the mouse. Trend. Genet. 12, 412-417, 1996
  • Forejt, J., Gregorova, S.: Genetic analysis of genomic imprinting: An Imprintor-1 gene controls inactivation of the paternal copy of the mouse Tme locus. Cell 70, 443-450, 1992.
  • Kralova, J., Jansa, P., Forejt, J.: A novel downstream regulatory element of the mouse H-2K b class I major histocompatibility gene. EMBO J. 11, 4591-4600,1992.
  • Forejt, J.: Spermatogenic failure of translocation heterozygotes affected by H-2 linked gene in mouse. Nature (London) 260,143-145, 1976.

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News

26.06.20

Reaction to the case of Tomáš Hudlický: Members of the Learned Society of the Czech Republic support the freedom of expression

„We believe that free exchange of ideas is a key condition for the pursuit of truth and that the honest opinions should be scrutinized, challenged or rebutted but not censored or suppressed,“ say 45 members of the Learned Society in a statement regarding the retracted opinion paper by Prof. Tomáš Hudlický.

24.06.20

The letter by Jan Konvalinka to the President and Vice-Chancellor of the Brock University regarding the retracted article of Prof. Tomáš Hudlický

Opinions could and should be challenged, questioned or refuted but never silenced. In order to be able to think, we have to have the right to inquire, question and even offend or be mistaken,” writes Assoc. Prof. Jan Konvalinka, a biochemist at the IOCB Prague and the Vice-Rector of the Charles University, to Gervan Fearon.

27.11.19

Prof Miroslav Bárta receives the Česká hlava National Government Award

Learned Society member, Prof. Mgr. Miroslav Bárta, Dr. (Charles University Faculty of Arts) received the Česká hlava (Czech Head) National Government Award on 25 November 2019. A renowned Czech Egyptologist and archaeologist, Professor Bárta researches the history of ancient civilisations, the human relationship to the natural environment, and also for many years the evolution of complex societies. He leads the Czech Institute of Egyptology for archaeological and environmental research in Egypt and Sudan. His principal research interest is the period of the pyramid builders of the Old Kingdom.