Bartůňková Jiřina

Prof., MUDr. DrSc., MBA

  • Alergology and Clinical Immunology
  • Member of Learned Society since 2015

Education and professional carreer

  • 1983-1988 Fellowship from clinical immunology resulting in PhD. degree,
  • 1989 post-graduate profess. examination - Internal diseases
  • 1991 post-graduated professional examination - Clinical immunology and allergology
  • 1995 ass.prof.: theme of thesis: The role of polymorphonuclear leukocytes in immunopathological diseases
  • 2003 full professorship
  • 2005 manager studies MBA (Prague International Business School)

Employment and academic positions

  • 1983-1995: Department of Clinical Immunology, Charles University, Prague (fellow, then lecturer)
  • 1995 - Institute of Immunology, 2nd Faculty of Medicine, Charles University, Prague, head, vice-dean 2000-2006

Research engagements: Phagocytic cells in health and disease, ANCA-associated diseases, Dendritic cells. Complex immunology program – coordinator of grant provided by Ministry of Education, 1999-2004, 2005-2011, 6th Fw EU project-Allostem (participant No4 out of 23 participants from Europe), NCEV (Nordic center of Excellence for antitumoral vaccines), 2003 - FOCIS center of Excellence – head of Czech FOCIS Center
Pedagogic engagement: teaching basic and clinical immunology in 3,4, and 5 year of Med. School,
Medical care: consultant in immunology for patients with immunopathological diseases

Membership

  • Czech Society for Clinical Immunology and Allergology (vice-president)
  • Czech Society for Immunology, Society for Leukocyte Biology
  • ESID (European society for immunodeficiency)
  • Clinical Immunology Society (USA), Nephrology Society
  • Czech Medical Academy

Notable awards

  • 1983 Rector's Award for outstanding academic achievement
  • 1987 Best scientific poster at the conference Esaote, Bruxelles
  • 1997 Award Janssen-Cilag for best publication (LAD syndrome)
  • 1999 Award dr. Lišky for the best publication in the field of clinical immunology and allergy at r. 1998 (textbook Immunology, Horejsi V., J. Bartůňková, Triton, Praha 1998)
  • 2003 Best case report in the journal Allergy (Price Schering Plough)
    Vernerová E., Bartůňková J .: Serotonin syndrome. Allergy 5,2003,4: 334-335
  • 2004 best original work in the journal Allergy (Schering Plough) Špíšek R., J. Brázová, Rožková D., K. Zapletalová, A. Šedivá, Bartůňková J .: Effect of clinically immunomodulators used in the maturation of dendritic cells. Allergy, 2004; 6 (1): 11 to 16
  • 2005 Award CZEDMA progress in the area of laboratory testing using in vitro diagnostics Bartůňková J, Šedivá A. Diagnostic and pathogenetic role of antineutrophil cytoplasmic autoantibodies. Clin Immunol. 2003 Feb; 106 (2): 73-82.
  • 2007 Magazine Award for Best Allergy Review article (Autoimmunity and Allergy) Bartůňková J., Kayserova .: Autoimmunity and allergies - yin and yang of immunopathology
  • 2007 Award per IPVZ publishing activities
  • 2008 Award ČIS “Granátový imunoglobulin (Garnet Immunoglobulin prize)” for long-term scientific contributions to the field of immunology
  • 2008 Award Dr. J. Lišky for the best publication in the field of allergy and clinical immunology, monograph Immunodeficiency
  • 2009 Award Director of the University Hospital for the Accomplishment of the Year 2008 (Project tumor vaccines)
  • 2015 Award Vladimir Zavázal ČSAKI for contribution to the Allergy and Clinical Immunology

Selected publications

  1. Podrazil M, Horvath R, Becht E, Rozkova D, Bilkova P, Sochorova K, Hromadkova H, Kayserova J, Vavrova K, Lastovicka J, Vrabcova P, Kubackova K, Gasova Z, Jarolim L, Babjuk M, Spisek R, Bartunkova J, Fucikova J. Phase I/II clinical trial of dendritic-cell based immunotherapy (DCVAC/PCa) combined with chemotherapy in patients with metastatic, castration-resistant prostate cancer. Oncotarget. 2015 May 29. [Epub ahead of print] PubMed PMID: 26078335.
  2. Fucikova J, Moserova I, Truxova I, Hermanova I, Vancurova I, Partlova S, Fialova A, Sojka L, Cartron PF, Houska M, Rob L, Bartunkova J, Spisek R. High hydrostatic pressure induces immunogenic cell death in human tumor cells. Int J Cancer. 2014 Sep 1;135(5):1165-77. doi: 10.1002/ijc.28766. Epub 2014 Feb 20. PubMed PMID: 24500981.
  3. Fialová A, Partlová S, Sojka L, Hromádková H, Brtnický T, Fučíková J, Kocián P, Rob L, Bartůňková J, Spíšek R. Dynamics of T-cell infiltration during the course of ovarian cancer: the gradual shift from a Th17 effector cell response to a predominant infiltration by regulatory T-cells. Int J Cancer. 2013 Mar 1;132(5):1070-9. doi: 10.1002/ijc.27759. Epub 2012 Aug 24. PubMed PMID: 22865582.
  4. Fučíková J, Rožková D, Ulčová H, Budinský V, Sochorová K, Pokorná K, Bartůňková J, Špíšek R. Poly I: C-activated dendritic cells that were generated in CellGro for use in cancer immunotherapy trials. J Transl Med. 2011 Dec 30;9:223. doi: 10.1186/1479-5876-9-223. PubMed PMID: 22208910; PubMed Central PMCID: PMC3259090.
  5. Fox BA, Schendel DJ, Butterfield LH, Aamdal S, Allison JP, Ascierto PA, Atkins MB, Bartunkova J, et al. Defining the critical hurdles in cancer immunotherapy. J Transl Med. 2011 Dec 14;9:214. doi: 10.1186/1479-5876-9-214. PubMed PMID: 22168571; PubMed Central PMCID: PMC3338100.
  6. Kocián P, Šedivcová M, Drgáč J, Cerná K, Hoch J, Kodet R, Bartůňková J, Špíšek R, Fialová A. Tumor-infiltrating lymphocytes and dendritic cells in human colorectal cancer: their relationship to KRAS mutational status and disease recurrence. Hum Immunol. 2011 Nov;72(11):1022-8. doi: 10.1016/j.humimm.2011.07.312. Epub 2011 Aug 16. PubMed PMID: 21884745.
  7. Fucikova J, Kralikova P, Fialova A, Brtnicky T, Rob L, Bartunkova J, Spísek R. Human tumor cells killed by anthracyclines induce a tumor-specific immune response. Cancer Res. 2011 Jul 15;71(14):4821-33. doi: 10.1158/0008-5472.CAN-11-0950. Epub 2011 May 20. PubMed PMID: 21602432.
  8. Sochorová K, Budinský V, Rozková D, Tobiasová Z, Dusilová-Sulková S, Spísek R, Bartůnková J. Paricalcitol (19-nor-1,25-dihydroxyvitamin D2) and calcitriol (1,25-dihydroxyvitamin D3) exert potent immunomodulatory effects on dendritic cells and inhibit induction of antigen-specific T cells. Clin Immunol. 2009 Oct;133(1):69-77. doi: 10.1016/j.clim.2009.06.011. Epub 2009 Aug 5. PubMed PMID: 19660988.
  9. Rozková D, Tiserová H, Fucíková J, Last'ovicka J, Podrazil M, Ulcová H, Budínský V, Prausová J, Linke Z, Minárik I, Sedivá A, Spísek R, Bartůnková J. FOCUS on FOCIS: combined chemo-immunotherapy for the treatment of hormone-refractory metastatic prostate cancer. Clin Immunol. 2009 Apr;131(1):1-10. doi: 10.1016/j.clim.2009.01.001. Epub 2009 Feb 8. Review. PubMed PMID: 19201656.
  10. Bartůnková J, Kayserová J, Shoenfeld Y. Allergy and autoimmunity: parallels and dissimilarity: the yin and yang of immunopathology. Autoimmun Rev. 2009 Feb;8(4):302-8. doi: 10.1016/j.autrev.2008.09.004. Epub 2008 Oct 9. Review. PubMed PMID: 18848649.

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