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Ulbrich Karel

Prof., Ing., DrSc.
Born February 27, 1947 in Prague, † 2019 

  • Macromolecular chemistry, biomedical polymers
  • Member of Learned Society since 2003

Educational and professional preparation

  • 1965, graduate, Parléř academic secondary school, Prague 6;
  • 1965-1970, Institute of Chemical Technology (ICT), Prague;
  • 1975, CSc., in macromolecular chemistry, Institute of Macromolecular Chemistry, Czechoslovak Academy of Sciences (IMC CSAS);
  • 2000, Associate Professor in macromolecular chemistry, ICT;
  • 2001, DrSc., IMC, Academy of Sciences of Czech Republic (AS CR).
  • 2005, Professor in macromolecular chemistry, ICT;

Employment and academic positions

  • 1971-1975, post-graduate student, IMC CSAS;
  • 1975-present, scientist at IMC, CS AS (later AS CR);
  • 1988-present, Head, Department of Biomedical Polymers, IMC, AS CR;
  • 1994-1998, Deputy Director, IMC, AS CR,
  • 1998-2007, Director of IMC AS CR;
  • 1992-present, adjunct associate professor, University of Utah (USA)

Membership in selected domestic scientific bodies

  • 2002-present, member Scientific Council, Tomáš Baťa University, Zlín;
  • 2003-present, member, Scientific Council, ICT;
  • 2008-present, member, Scientific Council, 1st Faculty of Medicine, Charles University, Prague;
  • 2009-present, member, Scientific Council, Faculty of Natural Sciences, Charles University, Prague;
  • 1999-present, member, Scientific Council, Polymer Institute, Slovak Academy of Sciences;
  • 1994-present, member, Scientific Council, Faculty of Chemical Technology of ICT;
  • 2003 present, Chairman, Commission for Granting the Title of Doctor of Science in Macromolecular Chemistry, AS CR;
  • 2009-present, chairman, Gremium for conferring the D.Sc. degree, AS CR;
  • 2007-present, member, Council of the Institute of Macromolecular Chemistry, AS CR;
  • 2007-present, member, Council of the Institute of Chemical Processes, AS CR;
  • 2007-present, member, Supervisory Board, Microbiology Institute, AS CR;
  • 2009-present, vice chairman, Scientific Board, AS CR;
  • 1991-2007; 2010-present, member, Academy Assembly, AS CR

Membership and positions in international organizations and societies

  • Member, Controlled Release Society
  • Member, International Union for Pure and Applied Chemistry (IUPAC)
  • Member, editorial boards of: J. Controlled Release, Europ. J. Pharm. Sci., J. Bioact. Biocompat.Polymers, Am. J. Drug Delivery, Central European Journal of Chemistry, J. Biomater. Sci., Polymer Edition
  • Member, international editorial advisory board of Polymer (Korea) and the journal Macromol. Biosci.
  • Member, Scientific Council, Polymer Institute, Slovak Academy of Sciences
  • 2005-present, member, Committee for conferring the Dr.Sc. degree in macromolecular chemistry and technology of macromolecular compound, Slovak Academy of Sciences;

Notable awards

  • 1996, Award, Learned Society of the Czech Republic (for work in macromolecular chemistry)
  • 2002, Award, Minister of Education, Youth and Sports (for the results of scientific work)
  • 2004, Honorary Medal of the Polymer Institute of Slovak Academy of Sciences
  • 2005, Award “Invence“, Česká hlava, Czech Republic
  • 2008, Award “Praemium Academiae 2008”, AS CR

Selected publications

  •  T. Etrych, J. Strohalm, L. Kovář, M. Kabešová, B. Říhová, K. Ulbrich, HPMA copolymer conjugates with reduced anti-CD20 antibody for cell-specific drug targeting. I. Synthesis and in vitro evaluation of binding efficacy and cytostatic activity. J. Controlled Release 140, 18-26 (2009)
  • K. Ulbrich, V. Šubr: Synthetic Polymer-Drug Conjugates for Human Therapy. Chapter 1 in Handbook of Materials for Nanomedicine. Volume 1: Materials for Nanomedicine: Organic Nanostructures (M.M. Amiji and V.P. Torchilin (eds.)), p. 5-79. Pan Stanford Publishing Pte Ltd 2010
  • R. Laga, Č. Koňák, V. Šubr, K. Ulbrich, New Hydrophilic HPMA-Based Polymers for Bioreversible Shielding of Gene Delivery Vectors. Macromol. Chem. Phys. 210, 1138-1148 (2009)
  • T. Etrych, L. Kovář, V. Šubr, A. Braunová, M. Pechar, P. Chytil, B. Říhová, K. Ulbrich, High-molecular-weight Polymers Containing Biodegradable Disulfide Bonds: Sunthesis and In Vitro Verification of Intracellular Degradation. J. Bioact. Compat. Polymers 25, 5-26 (2010)
  • K. Ulbrich, V. Šubr, Structural and chemical aspects of HPMA copolymers as drug carriers, Adv. Drug Delivery Rev. 62, 150-166 (2010)
  • T. Lammers, V. Šubr, K. Ulbrich, W. E. Hennink, G. Storm, F. Kiessling, Polymeric nanomedicines for image-guided drug delivery and tumor-targeted combination therapy. Nano Today 5, 197-212 (2010)
  • T. Etrych, M. Šírová, L. Starovoytova, B. Říhová, K. Ulbrich, HPMA copolymer conjugates of paclitaxel and docetaxel with pH-controlled drug release. Molecular Pharmaceutics 7, 1015-1026 (2010)
  • Říhová, B., Etrych, T., Šírová, M., Kovář, L., Hovorka, O., Kovář, M., Benda, A., Ulbrich, K., Synergistic action of doxorubicin bound to the polymeric carrier based on N-(2-hydroxypropyl)methacrylamide copolymers through amide or hydrazone bond. Molecular Pharmaceutics 7, 1027-1040 (2010)
  • R. Laga, Č. Koňák, V. Šubr, K. Ulbrich, N. Suthiwangcharoen, N. Zhongwei, Q. Wang, Chemical Conjugation of Cowpea Mosaic Viruses with Reactive HPMA-Based Polymers, J. Biomater. Sci. Polym. Ed. 21(12)1669-1685 (2010)
  • P. Chytil, T. Etrych, J. Kříž, V. Šubr, K. Ulbrich, N-(2-Hydroxypropyl)-methacrylamide-based polymer conjugates with pH-controlled activation of doxorubicin for cell-specific or passive tumour targeting. Synthesis by RAFT polymerisation and physicochemical characterisation. Europ. J. Pharm. Sci. 41, 473-482 (2010)
  • R.A. Willemsen, M. Pechar, R.C. Carlisle, E. Schooten, R. Pola, A.J. Thompson, L.W. Seymour and K. Ulbrich, Multi-component polymeric system for tumour cell-specific gene delivery using a universal bungarotoxin linker. Pharm. Res. 11 (27), 2274-2282, (2010)

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XXV. General Assembly of the Learned Society of the Czech Republic

The ceremonial part of the XXV. General Assembly of the Learned Society, at which the Medals of the Learned Society of the Czech Republic Societas Scientarium Bohemica Ad Laudem et Honorem and the awards of the Learned Society of the Czech Republic in the “Young Scientist” and “Grammar School Student” categories were presented, took place on Monday 20 May 2019 in the Great Hall of the Carolinum.


Bolzano lecture by prof. Kip S. Thorne

American physicist Kip S. Thorne, recipient of the Nobel Prize for 2017 for detection of gravitational waves, visited Prague at the invitation of he Learned Society. He held a series of “Bolzano lectures” and a lecture titled “Creating Gravitational-Wave Astronomy” for the Learned Society on 15 May 2019 in the Blue Auditorium of the Carolinum. The lecture was held with the support of the Karel Janeček Foundation and was received very enthusiastically.


XXV. General Assembly

The Czech Learned Society is holding its XXV. General Assembly on 20 and 21 May 2019. The Learned Society’s awards in the “Young Scientist” and “Grammar School Student” categories, Teaching Awards for pedagogic workers who promote interest in science and research at grammar schools and the Learned Society’s medals for meritorious contributions to the advance of science will be presented during a ceremony on 20 May at the Karolinum. Lectures by renowned scientists will also be presented. The second day will be reserved for the working part of the meeting, in the building of the Academy of Sciences of the Czech Republic.