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15.08.2017

Freudenberg Marina Alexandra

Prof. Dr. Med.
Born May 3, 1947 in Opava, Czechoslovakia

  • Immunology, innate imunity
  • Member of the Learned Society since 2017

Educational and professional preparation

  • Study of Medicine at the Charles University, Prague, Czechoslovakia and JW Goethe University, Frankfurt, Germany (1965-1971)
  • Licence to practice medicine (1972)
  • Doctoral thesis (1972-1974): Albrecht Ludwig University Freiburg
  • Habilitation in Experimental Microbiology (1995), member of the fakulty of medicine, Freiburg (since 1995)
  • Extraordinary Professor at the Albrecht Ludwig University Freiburg (since 2001)

Employment and academic positions

  • 1972-2012 Max-Planck-Institute of Immunobiology and Epigenetics, Freiburg Germany as doctoral student (1972-74), postdoc (1974-81), research scientist (1981-92) and staff member (1992-2012)
  • 2003-2008 External Professor at the Medical faculty, University of Bari, Italy
  • 2012 International professorship (Governmental program „Science without borders“) at the Universidade Federal de Sao Paulo UNIFESP, Brazil
  • since 2012 Scientific member at the Institute of Microbiology AS CR, Prague, Czech Republic
  • since 2013 as Guest Professor at the Albrecht Ludwig University Freiburg (at the at the Center for Biological Signalling Studies (BIOSS) and Department of Pneumology, University Medical Center)

Membership in selected domestic scientific bodies

  • Deutsche Gesellschaft für Immunologie

Notable awards

  • Sheldon E. Greisman  Award 2016 of the International Endotoxin and Innate Immunity Society for substantial and original contributions which have led to an increased understanding of the interactions between microorganisms and innate immunity.

Selected publications

  • Freudenberg, M.A., Bøg-Hansen, T.C., Back, U., Galanos, C. (1980). Interaction of lipopolysaccharides with plasma high-density lipoprotein in rats. Infect. Immun. 28, 373-380.
  • Katschinski, T., Galanos, C., Coumbos, A., Freudenberg, M.A. (1992): Gamma interferon mediates Propionibacterium acnes-induced hypersensitivity to lipopolysaccharide in mice. Infec Immun 60: 1994-2001
  • Poltorak, A., Merlin, T., Nielsen, P.J., Sandra, O., Smirnova, I., Schupp, I., Boehm, T., Galanos, C., Freudenberg, M.A. (2001): A point mutation in the IL-12R_2 gene underlies the IL-12 unresponsiveness of the LPSd C57Bl/10ScCr mice. J. Immunol. 167: 2106-2111.
  • Freudenberg, M., Merlin, T., Kalis, C., Chvatchko, Y., Stübig, H., Galanos, C. (2002). Cutting Edge: A Murine, IL-12-independent pathway of IFN-_ induction by gram-negative bacteria based on STAT4 activation by type I IFN and IL-18 signaling. J Immunol 169: 1665-1668
  • Kalis, C., Kanzler, B., Lembo, A., Poltorak, A., Galanos, C., Freudenberg, M.A. (2003). Toll-like receptor 4 expression levels determine the degree of LPS-susceptibility in mice. Eur J Immunol 33: 789-805
  • Huber, M., Kalis, C., Keck, S., Jiang, Z., Georgel, P., Du, X., Shamel, L., Sovath, S., Mudd, S., Beutler, B., Galanos, C., Freudenberg, M.A. (2006). R-form LPS, the master key to the activation of TLR4/MD-2-positive cells. Eur J Immunol 36: 701-711
  • Martin, S., Dudda, J.C., Bachtanian, E., Lembo, A., Burghard, S., Liller, S., Dürr, C., Fejer, G., Vassileva, R., Freudenberg, N., Heimesaat, M.M., Bereswill, S., Termeer, C.C., Johner, C., Galanos, C., Freudenberg, M.A. (2008). Toll-like receptor and IL-12 signaling control susceptibility to contact hypersensitivity. J Exp Med 9: 2151-62
  • Tchaptchet S., Gumenscheimer M., Kalis C., Freudenberg N., Hölscher C., Kirschning C.J, Lamers M., Galanos C., Freudenberg M.A. (2012). TLR9-dependent and independent pathways drive activation of the immune system by Propionibacterium acnes. PLoS One 7(6): e39155
  • Fejer G., Wegner M.D., Györy I., Cohen I., Engelhard P., Voronov E., Manke T., Ruzsics Z., Dölken L., Prazeres da Costa O., Branzk N., Huber M., Prasse A., Schneider R., Apte R.N., Galanos C., Freudenberg M.A. (2013). Nontransformed, GM-CSF-dependent macrophage lines are a unique model to study tissue macrophage functions. Proc Natl Acad Sci USA 110 (24): E2191-8
  • Maler M.D., Nielsen P.J., Stichling N., Cohen I., Ruzsics Z., Wood C., Engelhard P., Schamel W.W.A., Gordon S., Jakob T., Martin S.F., Jahnen-Dechent W., Greber U,F., Freudenberg M.A., Fejer G. (2017). Key role of the scavenger receptor MARCO in mediating 1 adenovirus infection and subsequent innate responses of macrophages. mBio in press