Holý Antonín

Prof. RNDr., DrSc.
Born September 1, 1936

  • Organic chemistry
  • Member of Learned Society since 1999

Employment and academic positions:

  • 1963-present, Institute of Organic Chemistry and Biochemistry AS CR (IOCB);
  • 1967, senior scientist;
  • 1983, Head, nucleic acid chemistry group;
  • 1986, DrSc.;
  • 1987, Head, Bioorganic Chemistry Department;
  • 1994-2002, Director, IOCB

Membership and positions in international organizations and societies:

  • International Union of Pure and Applied Chemistry
  • International Society for Antiviral Research
  • International Society of Nuclear Acids Chemistry
  • American Society for Microbiology

Notable awards:

  • 1998, Dr.h.c., Palacký University, Olomouc
  • 1998, Hanuš Medal, Czechoslovak Chemical Society
  • 1999, Descartes Prize of European Union
  • 2001, Elion Award, International Society for Antiviral Research
  • 2002, State Medal „For Merit“
  • 2004, Honorary Medal, AS CR, “De Scientia et humanitate optime meritis“

Selected publications:

  • De Clercq E., Holý A., Rosenberg I., Sakuma T., Balzarini J., Maudgal P. C.: A novel selective broad-spectrum anti-DNA virus agent. Nature 323, 464-467, 1986
  • De Clercq E., Sakuma T., Baba M., Pauwels R., Balzarini J., Rosenberg I., Holý A.: Antiviral activity of phosphonylmethoxyalkyl derivatives of purine and pyrimidines. Antiviral Res. 8, 261-272, 1987
  • Snoeck R., Sakuma T., De Clercq E., Rosenberg I., Holý A.: (S)-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine, a potent and selective inhibitor of human cytomegalovirus replication. Antimicrob. Agents Chemother. 32, 1839-1844, 1988
  • Balzarini J., Naesens L., Herdewijn P., Rosenberg I., Holý A., Pauwels R., Baba M., Johns D. G., De Clercq E.: Marked in vivo antiretrovirus activity of 9-(2-phosphonylmethoxyethyl)adenine, a selective anti-human immunodeficiency virus agent. Proc. Natl. Acad. Sci. U. S. A. 86, 332-336, 1989
  • Balzarini J., Holý A., Jindrich J., Naesens L., Snoeck R., Schols D., De Clercq E.: Differential antiherpesvirus and antiretrovirus effects of the (S) and (R) enantiomers of acyclic nucleoside phosphonates: potent and selective in vitro and in vivo antiretrovirus activities of (R)-9-(2-phospho-nomethoxypropyl)-2,6-diaminopurine. Antimicrob. Agents Chemother. 37, 332-338, 1993
  • Holý A., Gunter J., Dvořáková H., Masojídková M., Andrei G., Snoeck R., Balzarini J., De Clercq E.: Structure-antiviral activity relationship in the series of pyrimidine and purine N-[2-(2-phospho-nomethoxy)ethyl] nucleotide analogues. 1. Derivatives substituted at the carbon atoms of the base. J. Med. Chem. 42, 2064-2086, 1999
  • Holý A., Votruba I., Tloušťová E., Masojídková M.: Synthesis and cytostatic activity of N-[2-(phosphonomethoxy)alkyl] derivatives of N6-sub-stituted adenines, 2,6-diaminopurines and related compounds. Collect. Czech. Chem. Commun. 66, 1545-1592, 2001
  • Balzarini J., Pannecouque C., De Clercq E., Aquaro S., Perno C. F., Egberink H., Holý A.: Antiretrovirus activity of a novel class of acyclic pyrimidine nucleoside phosphonates. Antimicrob. Agents Chemother 46, 2185-2193, 2002
  • Holý A., Votruba I., Masojidková M., Andrei G., Snoeck R., Naesens L., De Clercq E., Balzarini J.: 6-[2-(Phosphonomethoxy)alkoxy]pyrimidines with antiviral activity. J. Med. Chem. 45, 1918-1929, 2002
  • Keith K. A., Hitchcock M. J. M., Lee W. A., Holý A., Kern E. R.: Evaluation of Phosphonate Nucleotides, Their Analogs and Prodrugs for Inhibition of Orthopoxvirus Replication. Antimicrob. Agents Chemother. 47, 2193-2198, 2003

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